In a talk about whether adults really need friends, someone asks about the people who think friends are necessary.
The words appear when the audience laughs.
地元の友達と離れるとかマジあれだよ
Being away from your hometown friends is seriously, like... you know.
Textbook地元の友達と離れるのは、本当に大変なことですよ。「マジ」 is slang for 「本当に」 ('seriously'), used here as an intensifier; 「あれだよ」 vaguely stands in for 'hard', textbook 「大変です」.