Literally “a lie”, but in speech うそ！ means “no way!”. Nobody is being called a liar.
うそ！ is a normal gasp of surprise, not an accusation. Fine with friends and coworkers.
A student warns Grandpa that the university is two hours away, making first-period mornings hard.
No way!
Textbook本当ですか。"嘘でしょ" (short for "嘘でしょう", "that must be a lie") works as a stunned "No way!", not an accusation; a textbook asks "本当ですか".
Two people have traveled from the future into the past, and one asks if they can still go back.
You've gotta be kidding me!?
Textbook本当ですか！？Where a textbook asks 「本当ですか」, speech blurts 「嘘」 'a lie': 「嘘だろ!?」 shows disbelief, not a real accusation of lying.
A crew of criminals using code names is in the middle of a job that depends on a computer.
No way!
Textbook本当ですか。「うそ」 literally means 'a lie', but blurted as 「うそ！」 it is shocked disbelief ('no way!'), the casual version of 「本当ですか」.
From other routines in the library. Automatic transcripts, not yet checked line by line.
うそ！／うそでしょ means “no way!”. Literally “a lie”, but in speech うそ！ means “no way!”. Nobody is being called a liar.
With friends: OK. With coworkers: OK. With a boss or teacher: careful. うそ！ is a normal gasp of surprise, not an accusation. Fine with friends and coworkers.
In 1,905 live comedy routines, うそ！／うそでしょ appears in 835 lines from 177 comedians.